- Title
- The Mechanistic Roles of Sirtuins in Breast and Prostate Cancer
- Creator
- Onyiba, Cosmos Ifeanyi; Scarlett, Christopher J.; Weidenhofer, Judith
- Relation
- Cancers Vol. 14, Issue 20, no. 5118
- Publisher Link
- http://dx.doi.org/10.3390/cancers14205118
- Publisher
- MDPI AG
- Resource Type
- journal article
- Date
- 2022
- Description
- Mammalian sirtuins (SIRT1-7) are involved in a myriad of cellular processes, including apoptosis, proliferation, differentiation, epithelial-mesenchymal transition, aging, DNA repair, senescence, viability, survival, and stress response. In this review, we discuss the current information on the mechanistic roles of SIRT1-7 and their downstream effects (tumor promotion or suppression) in cancers of the breast and prostate. Specifically, we highlight the involvement of sirtuins in the regulation of various proteins implicated in proliferation, apoptosis, autophagy, chemoresistance, invasion, migration, and metastasis of breast and prostate cancer. Additionally, we highlight the available information regarding SIRT1-7 regulation by miRNAs, laying much emphasis on the consequences in the progression of breast and prostate cancer.
- Subject
- sirtuins; breast; prostate; cancer; tumor; miRNA; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1490694
- Identifier
- uon:52962
- Identifier
- ISSN:2072-6694
- Rights
- © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- Language
- eng
- Full Text
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